CDKN2A and osteosarcoma: Using a comparison of infused normal MSCs, in vitro spontaneously transformed MSCs, and osteosarcoma murine cells, Mohseny and co-workers [100] concluded that aneuploidy, chromosomal translocations and the homozygous loss of the Cdkn2A (p16) locus on chromosome 4 were implicated in tumour progression.