Other commonly used additional markers include staining of the biopsy for lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase, c-kit, interstitial cells of Cajal (ICC) or silver staining and S-100 staining [1]. The gene discussed is KIT; the disease is intrahepatic cholangiocarcinoma.