Persons recorded as having diabetes if they said they had the disease and reported dietary or pharmacological treatment with oral antidiabetics or insulin. Persons were considered to have undetected type 2 diabetes if they were unaware of disease at time of inclusion in study but had two consecutive FPG values ≥ 7 mmol/L (≥ 126 mg/dL). The gene discussed is INS; the disease is diabetes mellitus.