CD46 and atypical hemolytic-uremic syndrome: Impressive progress has been done during the last decade, showing that 4 regulatory proteins of the complement alternative pathway, complement factor H (CFH), membrane cofactor protein (MCP or CD46), factor I (CFI) and thrombomodulin (THBD) and 2 proteins of the C3 convertase, C3 and factor B (CFB), had a role in the pathogenesis of aHUS.