CREBBP and myelodysplastic syndrome: One further tantalizing connection is that mice haploinsufficient for Crebbp expression develop myelodysplastic disease within their first year of life (manuscript submitted) and IRF1 has also been implicated in the pathophysiology of immune-mediated marrow failure in myelodysplastic syndrome[70] and is frequently deleted in 5q- myelodysplasia[71].