TP53 and neoplasm: TP53 mutations were more frequent in distal tumours: 21 of 60 distal tumours (35.0%) were mutated compared to only 7 of 43 proximal tumours (16.3%, P = 0.0440), and in invading tumours: 17 of 43 invading tumours (39.5%) were mutated compared to only 9 of 56 non-invading tumours (16.1%, P = 0.0114, 4 tumours lacked information).