OCRL and oculocerebrorenal syndrome: The presence in OCRL1 of binding sites for clathrin, the adaptor protein AP-2, the endocytic adaptor APPL1, and other endocytic proteins [20], [21] strengthens the link to endocytosis [22], [23], [24], which tends to support the proposition that the tubulopathy of Lowe Syndrome derives from altered trafficking of megalin [23], [24].