TP53 and Familial prostate cancer: Adams et al. showed that EF24 caused G2/M phase cell cycle arrest in both MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells [28], and Selvendiran et al reported that the inhibitory effect of EF24 on cisplatin-resistant(CR) human ovarian cancer cell proliferation is associated with G2/M phase cell cycle arrest and increased G2/M checkpoint protein (pp53, p53, and p21) levels [35].