These results further expand previous reports of miR-143-mediated ERK5 expression knockdown in colon cancer cell lines in vitro[11], [12], and are in agreement with reduced ERK5 expression following repeated (3x) miR-143 intratumoral injection and in vivo electroporation in prostate cancer cell tumor xenografts [20]. This evidence concerns the gene MAPK7 and Familial prostate cancer.