Although their study shows an effect in the opposite direction to the apparent effect of a CIMP-high score seen here, it is important to stress that the determination of CIMP in our study was based on a validated eight gene screening panel [25] and is thus an indication that the tumours have a high frequency of hypermethylated genes in general, whereas Wang et al [21] focused on methylation of sites directly relevant to the Cnr1 gene. Here, CNR1 is linked to neoplasm.