For example, previous studies of endometrial carcinomas have uncovered somatic alterations of a number of genes implicated in the maintenance of genomic integrity including somatic mutations in CDC4/FBXW7, and p53, and amplification or altered expression of STK15, BUB1, CCNB2, and CCNE[30]–[33]. This evidence concerns the gene CCNE1 and endometrial carcinoma.