M45-specific CD8 T cell responses in mice lacking CD4 T cells were largely comparable to wild type mice and M38-specific CD8 T cell responses were generally increased in MHCII-/- and CD4-/- mice, indicating that MCMV-specific CD8 T cell responses in the SG were not impaired in absence of CD4 T cells up to 120 days post infection. This evidence concerns the gene CD4 and infection.