MAPT and Alzheimer disease: Although genetic markers of the genes examined in this study (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) were not found associated to AD in the largest GWA study [5], our main hypothesis was that common variation in genes directly related to tau dephosphorylation in the PP2A pathway might underlie individual differences in susceptibility to AD.