Although genetic markers of the genes examined in this study (PPP2CA, PPP2R2A, ANP32A, LCMT1, PPME1 and PIN1) were not found associated to AD in the largest GWA study [5], our main hypothesis was that common variation in genes directly related to tau dephosphorylation in the PP2A pathway might underlie individual differences in susceptibility to AD. Here, PPP2CA is linked to Alzheimer disease.