At 8 months of age (6 month time point), APP/PS1; Col1-IL1βXAT mice suffering from osteoarthritis displayed increased numbers of Aβ plaques throughout their brain compared to age- and gender- matched APP/PS1 mice, with an apparent preponderance of large diameter (> 100 μm) plaques (Figure 3C-D). The gene discussed is APP; the disease is osteoarthritis.