INS and polycystic ovary syndrome: The remainder of this document will: 1) discuss the primary modalities available for the treatment of PCOS; 2) review the literature that compares and contrasts their efficacy, alone or in combination; 3) where available, evaluate the data concerning treatment of a late adolescent PCOS population; and 4) consider whether insulin sensitization, given the role insulin may play in promoting androgen production, should be considered as first-line therapy for the treatment of adolescents with PCOS.