Ibanez and colleagues define hyperinsulinemia as a peak insulin of > 150 μU/mL during a 2-hr oral glucose tolerance test and/or mean serum insulin levels of > 84 μIU/mL during standard oral glucose tolerance testing [54,55,104,189,190,192,195,206,221-223,229-232]. This evidence concerns the gene INS and Hyperinsulinemia.