SERPINE1 and polycystic ovary syndrome: In adults with PCOS, increased abdominal fat, decreased insulin sensitivity, and endothelial dysfunction also contribute to increased cardiovascular risk, and are associated with alterations in circulating levels of adipocytokines; cardiovascular risk markers such as endothelin-1, plasminogen activator-1 (PAI-1), and lipoprotein (a); pro-inflammatory markers such as IL-1, TNF-α, and CRP; and higher neutrophil counts [174-186].