In 36 adolescent obese girls with PCOS randomized for six months to a combined pill (ethinyl estradiol + drosperinone) with lifestyle intervention and metformin (2000 mg daily) or to an OCP with lifestyle intervention and placebo, weight reductions, increases in SHBG, and decreases in free androgen index, and decreases in hirsutism scores occurred in both groups, but did not differ between groups [133]. Here, SHBG is linked to polycystic ovary syndrome.