INS and polycystic ovary syndrome: However, in an uncontrolled study, Glueck reported that metformin therapy associated with caloric restriction for 12 months in 35 adolescents with PCOS was associated with a 4.4% decrease in weight, as well as decreases in insulin, HOMA-IR (an index of insulin sensitivity derived from fasting glucose and insulin values), cholesterol and TG, and improved menstrual function, with regular monthly cycles increasing from 22% to 74% [217].