Vuguin [233] and Silfen [234] demonstrated good correlation between fasting glucose:insulin ratios of < 7 mg/10-4 IU and IVGTT measures of IR in adolescents with premature adrenarche, substantially greater than the figure determined for IR associated with adult PCOS (approximately, 4.5 mg/10-4 IU) [235]. This evidence concerns the gene INS and polycystic ovary syndrome.