In order to contribute to the elucidation of HCDR3 stereotyping in CLL, we characterized the BCR repertoire in a comprehensive panel of 1126 patients with the following aims: (a) to investigate whether HCDR3 stereotyped sequences might be correlated with molecular and cytogenetic profiles; and (b) to evaluate the putative clinical relevance in terms of TTFT for the most represented stereotypes. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.