We previously found that in vivo BTC expression by delivery of a recombinant adenovirus expressing BTC (rAd-BTC) remitted hyperglycemia in STZ-induced diabetic mice by beta cell regeneration [9], and some studies showed that new beta cells by BTC are generated mainly by replication of pre-existing beta cells [9], [30]. The gene discussed is BTC; the disease is Hyperglycemia.