Twenty-two members of the family (Figure 1), including eleven affected individuals were genotyped with microsatellite markers at 11 candidate loci for autosomal dominant cataract on chromosomes 1q (GJA8), 2q (CRYGC, CRYGD), 3q (BFSP2), 11q (CRYAB), 12q (MIP), 13q (GJA3), 16q (HSF4), 17q (CRYBA1), 19q (LIM2), 21q (CRYAA), and 22q (CRYBB1–3, CRYBA4). This evidence concerns the gene HSF4 and Autosomal dominant optic atrophy and cataract.