Twenty-two members of the family (Figure 1), including eleven affected individuals were genotyped with microsatellite markers at 11 candidate loci for autosomal dominant cataract on chromosomes 1q (GJA8), 2q (CRYGC, CRYGD), 3q (BFSP2), 11q (CRYAB), 12q (MIP), 13q (GJA3), 16q (HSF4), 17q (CRYBA1), 19q (LIM2), 21q (CRYAA), and 22q (CRYBB1–3, CRYBA4). The gene discussed is HSF4; the disease is autosomal dominant cataract.