In angiogenetic roles, emerging evidence has demonstrated that TGF-β, the other superfamily member, may definitely stimulate angiogenesis during the late stage of cancer (Jakowlew, 2006), while neuroblastoma cells with restored activin A expression exhibit a decreased tumour growth and reduced vascularity (Panopoulou et al, 2005). Here, TGFB1 is linked to cancer.