Transpliced RAZ, containing ZANK but not capable of ZEBRA DNA binding would then serve as an amplifier of the NF-κB and p53 protein functions of ZEBRA, and a corresponding RAZ-like function might explain the non-DNA binding functions of a ZEBRA homologue in HSV-8, the etiologic agent of Kaposi's sarcoma and other human cancers. This evidence concerns the gene TP53 and Kaposi's sarcoma.