An inverse relationship between ER and PR expression and high tumour grade has been previously documented (Millis, 1980) and was also noted for the Nigerian tumours (p = 0.006 for ER and p = 0.002 for PR) but there was a less significant trend for the British tumours (p = 0.053 for ER and p = 0.014 for PR). This evidence concerns the gene PGR and neoplasm.