HSC70 has been found on the cell surface as HSP70-1 and/or HSP70-2 and is released to extracellular space in the K562 erythroleukemic cells treated with pro-inflammatory cytokine interferon-gamma (IFN-γ).78 Likewise, HSC70 co-localizes with tumor antigens and MHC class I molecules in the exosome released from 2 different types of MHC-mouse cell lines including CT26 (H-2d MHC) and TA3HA (H-2a MHC).85 The HSC70-contained exosomes activate dendritic cells and suppress tumor size in the colon cancer-bearing mice.85 This evidence concerns the gene HSPA8 and malignant colon neoplasm.