Furthermore, Pep42 conjugated with the apoptosis-inducing oligopeptide (AIO) or photosensitizer decreases viability of tumor cells, such as A549 and HepG2 cells; whereas the effect is not observed in normal cells.105 Likewise, the GRP78 binding peptides, WIFPWIQL or WDLAWMFRLPVG, fused with AIO decreases the tumor size in the xenograft mice with prostate and breast cancers.106. Here, HSPA5 is linked to breast cancer.