GRP75 shows induced-expression in many types of brain tumors including meningiomas, neurinomas, pituitary adenomas and metastases.62 The mRNA level of GRP75 is upraised in tumor tissues of breast, brain, and colon tumors in the mouse model.63 The gene HSPA9 expression in most of tumor or immortalized cell is higher than that in normal cells.63 Malignancy of breast cancer is enhanced in GRP75-overexpressed cells.63 Besides, elevated expression of GRP75 decreases survival of the patient with colon cancer.64 This evidence concerns the gene HSPA9 and pituitary gland adenoma.