TP53 and cancer: Overexpression of HSP70s is significantly associated with tumor transformation since HSP70s may block apoptosis to adapt adverse microenvironments as mentioned above or chaperone the mutated proteins of cancer cells, such as mutated p53, which is observed in approximately 50% cancers.21,45 Moreover, the level of HSP70s is reportedly increased in a variety of tumor cells or tissues as followings (Table 2).