The human chromosome 9p21 locus has three different genes that have tumor suppressor functions, namely cyclin-dependent kinase inhibitor 2A (CDKN2A): p16INK4a and p14ARF (INK4a/ARF) and CDKN2B: p15INK4b, respectively (Sherr, 2004). Here, CDKN2A is linked to neoplasm.