Thus, freely moving GAT-1 KO mice, which have an enhanced tonic GABAA current in TC neurons, express ethosuximide-sensitive absence seizures (Fig. 2B1), and intrathalamic injection of no.711, a selective GAT-1 blocker, in normal Wistar rats initiates absence seizures (Fig. 2B2). This evidence concerns the gene SLC6A1 and Generalized non-motor (absence) seizure.