Until further knowledge about the role of cyclin D1 in CRC has been gained, we believe that evaluation of the fraction and intensity of cyclin D1 as separate categories makes sense, not least in light of previous studies in breast cancer, for which the intensity, but not fraction, of cyclin D1 expression was found to influence survival and response to antihormonal therapy [40,43]. Here, CCND1 is linked to breast carcinoma.