Notably, all associations between cyclin D1 expression and survival were similar when overall survival was used as the endpoint, and because the number of events for cancer-specific and overall survival was identical for patients with metastatic disease, with a median survival of approximately 10.5 months (range 0 to 72), the use of CSS should be a reasonable surrogate for cancer-specific outcome. Here, CCND1 is linked to metastatic neoplasm.