CCND1 and colorectal carcinoma: A potential involvement of cyclin D1 in the pathway to CRC, involving mismatch repair, has also been suggested [37], and in the study by Ogino et al., an interaction between cyclin D1 expression and microsatellite instability (MSI) status was reported; the presence of either cyclin D1 or high MSI, or both, was associated with a better prognosis [29].