Univariate analysis showed that high MAP-tau expression and ER and PR positive status were associated with significantly better OS (hazard ratio (HR) = 0.766 and 0.675; 95% confidence interval (CI), 0.598 to 0.981 and 0.524 to.871, P = 0.0005 and P < 0.0001, respectively), while large tumor size, nodal metastasis, increasing number of positive nodes, total nodes, and nuclear grade, were associated with worse OS (Table 3). This evidence concerns the gene ESR1 and neoplasm.