Collagen type X deficiency may impact the supporting properties of the growth plate and the mineralization process, resulting in abnormal trabecular bone.(3) Regulatory dysfunctions of Col10a1 have been closely linked to altered chondrocyte maturation that has been observed in multiple skeletal dysplasias, bone repair and regeneration, as well as in the pathogenesis of osteoarthritis.4–9. This evidence concerns the gene COL10A1 and osteoarthritis.