High-resolution genomic profiling of pancreatic cancer cell lines and early-passage xenografts defined a 325 Kb minimal amplicon spanning SMURF1. Transcript levels of SMURF1 were elevated in specimens with gain/amplification, and by FISH we confirmed SMURF1 amplification in primary pancreatic cancers. The gene discussed is SMURF1; the disease is familial pancreatic carcinoma.