S1PR3 and myeloid sarcoma: In experimental autoimmune encephalomyelitis (EAE), an animal model commonly used to study inflammatory aspects of MS, S1P receptors were shown to be differentially regulated as S1P1 and S1P5 mRNAs were downregulated at days 11 and 29 in spinal cord, whereas S1P4 and S1P3 mRNAs were upregulated [17].