PTTG1 and Survivin showed a high prevalence of cytoplasmic staining (PTTG1- 79% in AD and 69% in SCC; Survivin- 73% in AD and 61% in SCC), as well as nuclear staining (PTTG1- 35% in AD and 49% in SCC; Survivin- 44% in AD and 33% in SCC). Here, PTTG1 is linked to Alzheimer disease.