Very few tumor samples (4 cases) express nuclear but not cytoplasmic CDK1, suggesting that loss of proteins such as 14-3-3σ that sequester CDK1 in the cytoplasm might contribute to this finding [20], [21], but loss or reduction of 14-3-3σ is very rare in primary NSCLC specimens [4]. This evidence concerns the gene CDK1 and neoplasm.