CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: We then examined whether Icaritin may induce CD34+ cells apoptosis in 4 cases with CML (1 for Imatinib resistance; 3 for CML-BC) and Imatinib-resistant cells line, As shown in Fig 2G, Icaritin could induce cells apoptosis significantly both on CD34+ CML and Imatinib-resistant cells.