MMP12 and coronary artery disorder: The associations between the MMP12 N122S variant and CHD and CCHD were also modestly significant (P = 0.04 and P = 0.01, respectively), with participants with the minor allele homozygote (GG) genotype having a 30% increased risk of CHD or CCHD compared to participants having the common AA genotype (for CHD HR = 1.00 for AA, 0.95 for AG, 1.36 for GG; P = 0.04; for CCHD HR = 1.00 for AA, 0.95 for AG, 1.31 for GG; P = 0.01).