The top 10 ranked biologic functions associated with commonly upregulated miRNAs include regulation of axon guidance, the MAPK signaling pathway, focal adhesion, ErbB signaling pathway, actin cytoskeleton, Wnt signaling pathway, GnRH signaling pathway, insulin signaling pathway, glioma, and renal cell carcinoma (Table S2). The gene discussed is INS; the disease is renal cell carcinoma.