The top 10 ranked biologic functions associated with commonly downregulated miRNAs included axon guidance, the MAPK signaling pathway, pancreatic cancer, focal adhesion, renal cell carcinoma, TGF-beta signaling pathway, insulin signaling pathway, Wnt signaling pathway, mTOR signaling pathway, prostate cancer, adhere junction, the ErbB signaling pathway, glioma, and regulation of actin cytoskeleton (Table S2). The gene discussed is INS; the disease is hereditary clear cell renal cell carcinoma.