In addition to miR-124a, stroke downregulates miR-9 and miR-139 in neural progenitor cells and these miRNAs have been predicted to target Notch and Hes1 [34] (www.targetscan.org), suggesting that miR-9 and miR-139 could also regulate the Notch signaling pathway after stroke. The gene discussed is HES1; the disease is stroke disorder.