PEA15 and breast carcinoma: Bartholomeusz and colleagues used RPPAs to measure PEA-15 (also called PED), which is believed to be a novel regulator of the ERK/MAP kinase pathway, in 320 human breast cancers and discovered that low expression of PEA-15 is correlated with high nuclear grade and negative hormone receptor status [150], suggesting its therapeutic potential as a druggable target in breast cancer.