UCHL5 and cervical carcinoma: Rolén et al. used this strategy to profile the activities of individual ubiquitin-specific proteases (USPs) in biopsies of HPV carrying cervical carcinoma and adjacent normal tissue, and as a result, they discovered that ubiquitin-carboxy hydrolase-L3 (UCHL3) and UCH37 are increased in HPV-positive tumors [131], which encourages further consideration of its use as therapeutic targets in cervical cancer.