We found a negative correlation of EZH2 and MLL1 expression (PCC = −0.56) in colon cancer and positive correlation of EZH2 and KDM1A expression (PCC = 0.65) in lung cancer, suggesting cooperation between H3K27 methylation and H3K4 demethylation. Here, KDM1A is linked to malignant colon neoplasm.