Furthermore, a number of shared epistatic genes in the two populations (Table S2) suggested links between SUA levels and various diseases such as autism (CNTNAP2, POU6F2, MYO1D), schizophrenia and bipolar disorder (ERC2, ROBO1, ROBO2, CNTNAP2, GRM7, SYNE1, CNTN5, ANKS1B), Alzheimer's disease (EPHA4, CNTN4, ADCY8, PCSK5, CUBN, SORCS1, RORA, GRIN2A), Parkinson's disease (DLG2), sclerosis (RGS7, CNTN4, IGF2R, SH3GL2, GPC5, GPC6, GRIN2A, MYH9), and diabetes (CD69, PTPRD, SORCS1, PREX1). This evidence concerns the gene CUBN and Alzheimer disease.