Furthermore, a number of shared epistatic genes in the two populations (Table S2) suggested links between SUA levels and various diseases such as autism (CNTNAP2, POU6F2, MYO1D), schizophrenia and bipolar disorder (ERC2, ROBO1, ROBO2, CNTNAP2, GRM7, SYNE1, CNTN5, ANKS1B), Alzheimer's disease (EPHA4, CNTN4, ADCY8, PCSK5, CUBN, SORCS1, RORA, GRIN2A), Parkinson's disease (DLG2), sclerosis (RGS7, CNTN4, IGF2R, SH3GL2, GPC5, GPC6, GRIN2A, MYH9), and diabetes (CD69, PTPRD, SORCS1, PREX1). The gene discussed is SYNE1; the disease is early-onset autosomal dominant Alzheimer disease.