GZMB and breast carcinoma: The wild type QPY genotype was associated with an increased incidence of Epstein-Barr-virus-associated hemophagocytic lymphohistiocytosis (HLH) in children.[32] Conversely, a subsequent study reported an association of the mutant RAH genotype with the incidence of breast cancer.[33] However, to link the genetic susceptibility of granzyme B to disease based on the presented data is difficult, because no patient developed HLH or breast cancer following HSCT in the current cohort.