HLA-DRB1 and coinfection: In univariate analysis, increased age by year, BMI<16.0, HIV co-infection and the number of HLA-DRB1*0701 alleles carried by patients showed significant associations with the negative results (OR = 1.04 [95%CI, 1.01–1.06], 7.27 [95%CI, 2.17–24.38], 4.26 [95%CI, 1.48–12.28], and 5.47 [95%CI, 2.58–11.61] respectively) (table 4).