Mean Endoglin concentration was 4.3±1.2 ng/mL among those with preserved renal function, 4.5±1.7 ng/mL in stage 2 CKD, 4.7±1.6 ng/mL in stage 3 CKD, 5.4±2.4 ng/mL in stage 4/5 CKD, and 4.2±1.1 ng/mL in individuals with ESRD, (P = 0.12). This evidence concerns the gene ENG and chronic kidney disease.