ECT2 and non-small cell lung carcinoma: In addition, it has recently been reported that Ect2 is overexpressed and mislocalized to the cytoplasm in human non small cell lung cancer, as a result of phosphorylation at residue T328 by PKCι [39], [44], Since we showed here that nuclear localization of Ect2 is required for its degradation at mitosis exit, it is possible that T328-phosphorylated Ect2 may escape degradation.