However, given the comparison was performed between the highest and lowest IgM groups and the difference was relatively minor, we concluded that IgM may only play a minor role in viral clearance during human influenza infection, this was also evidenced in the groups with modest units of IgM (the 2nd and 3rd quartiles of IgM units) in which only minor differences were observed in their clearance days from those two extreme groups (Figure S1b). The gene discussed is CD40LG; the disease is influenza.