TP53 and pancreatic intraductal papillary-mucinous neoplasm: Nonetheless, mutational inactivation of TP53 is a late event during PanIN multistep progression to PDAC (0% in PanIN-1 to 12% in PanIN-3) and seems to be more frequent in IPMN (30% in IPMN adenoma, 30% in IPMN borderline and in IPMC 50-63%) [2, 13, 53, 56, 58].