In this study, we investigated RNA expression of genes encoding Ang-1, Ang-2, Tie2, VEGF-A and VEGF-C by real-time quantitative polymerase chain reaction (RQ-PCR) in a cohort of 208 patients with newly diagnosed primary MDS and correlated the results with clinical features and outcome of the patients. This evidence concerns the gene ANGPT1 and myelodysplastic syndrome.