Likewise, the up-regulation of UCH-L1 in human hepatoma cells following low dose UV irradiation was reported to be involved in the regulation of cell death by inhibition of p53-mediated apoptosis; hence in both these cases UCH-L1 was demonstrated to be an "apoptosis-evading protein" [39], as in the present study. The gene discussed is UCHL1; the disease is hepatocellular carcinoma.