TNF and spondyloarthropathy: In effect, changes in the levels of these biomarkers were shown to be useful in making predictions regarding the clinical responses of patients with spondyloarthropathy to infliximab [45] but were somewhat in conflict with the results reported by De Rycke et al. [43] who determined that anti-TNF-α therapy appeared to alter the expression of cell-specific CD163 as well as CD68.