The MRP-8/14 complex, in particular, has been proposed to play a critical role in regulating several of the inflammatory responses associated with RA because both MRP-8 and MRP-14 can promote chronic inflammation and act to recruit neutrophils and monocytes to inflamed tissue by enhancing their migration, retention, and attachment to the endothelium [6]. The gene discussed is S100A9; the disease is rheumatoid arthritis.