MAPT and early-onset autosomal dominant Alzheimer disease: The endpoints that were examined included various CSF Aβ species (1-37, 1-38, 1-39, 1-40, and 1-42 species), tau and phospho-tau (thr181) levels and cognitive function, assessed using the Alzheimer's Disease Assessment Scale (ADAS-cog) and the minimental state examination (MMSE).