The loss of MecP2 results in dysregulation of multiple genes, including the downregulation of GABRB3. Furthermore, the loss of MecP2 is particularly detrimental to interneurons and a conditional MecP2 ablation in GABAergic neurons in mice was recently shown to recapitulate most of the behavioral anomalies associated with Rett syndrome, including autistic-like behavior [158]. Here, MECP2 is linked to Rett syndrome.