Interestingly, hypostimulation of PV-positive basket cells via selective ablation of the NR1 subunit of the NMDA receptors in these cells resulted in schizophrenia-like behaviors (working memory deficits, impaired prepulse inhibition, locomotor hyperactivity, and anxiety) and decreased PV and GAD67 expression in PV basket cells in a mouse model of schizophrenia [128]. The gene discussed is GAD1; the disease is schizophrenia.