For many years, physicians have had the mistaken idea that hypertension was a result of ageing and that treatment was not necessary and no common criteria existed about the therapy on these cases; some proposed no treatment, others suggested low-dose diuretics, and others recommended the use of other pharmacological groups (angiotensin-converting enzymes inhibitors, calcium channel blocker, or angiotensin-II receptor antagonists). This evidence concerns the gene ACE and hypertensive disorder.