MIF and chronic kidney disease: Zaza et al. demonstrated in peripheral polymorphonuclear cells from CKD patients through genomic studies involving more than 15,000 candidate genes that MIF, CXCL12, and IL8RB genes were independently associated with inflammation, and CXCL12 and IL8RB genes were inversely correlated to C reactive protein (CRP) and highly expressed in peritoneal dialysis patients and CKD, respectively [38].