Our study was designed to assess association of common single nucleotide polymorphisms (SNPs) in four key genes of the canonical Wnt/β-catenin signalling pathway (AXIN2, CTNNB1, LRP5 and LRP6) with DN using a case-control design involving 1467 individuals with type 1 diabetes. This evidence concerns the gene CTNNB1 and type 1 diabetes mellitus.